Yes, by using the rs command line utility.
you need to write a script file that would serve as the input file to the rs command.
besides you need to mention the server and filepath of the RDLs...
eg:
rs -i test.rss -s <A href="http:///reportserver">http://<host>/reportserver -v filePath="F:/RS/TESTREPORTS/"
you will find on online msdn, samples scripts illustrating the use of rs.CreateReport http://msdn2.microsoft.com/en-us/library/aa225813(SQL.80).aspx
and rs.CreateDatasource...
http://msdn2.microsoft.com/en-us/library/aa225833(SQL.80).aspx