We originally were running Netop and tried PC-Duo and found TS/RA to be quite agreeable on memory in comparison. However, keep I would say mutiple TS/RA connections at the same time will cause performance issues but that is the case with any process that can do this as there is a lot of network traffic involved. Make sure you optimize the connection by turning off some of the extra crap such as background and so on if you have that enabled. And be sure that the drive your Documents and Settings folder is on has plenty of space since each user will get their own profile under this.